Volume 1.32 | Nov 30

Pancreatic Cell News 1.32, November 30, 2010.

TOP STORY 

Class IA Phosphatidylinositol 3-Kinase in Pancreatic Beta Cells Controls Insulin Secretion by Multiple Mechanisms  ShareThis
Inhibition of class IA phosphatidylinositol 3-kinase, using a mouse model lacking the pik3r1 gene specifically in beta cells and the pik3r2 gene systemically, results in glucose intolerance and reduced insulin secretion in response to glucose. [Cell Metab]

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SCIENCE NEWS

Type 1 Diabetes Mortality Rates Dropping
Mortality rates for people with type 1 diabetes are decreasing, but overall remain seven times higher than those of the general population — likely as a result of long-term complications. [Press release from the American Diabetes Association discussing online prepublication in Diabetes Care]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

DIABETES

Identification of 9-Cis-Retinoic Acid as a Pancreas-Specific Autacoid That Attenuates Glucose-Stimulated Insulin Secretion
Data establish 9-cis-retinoic acid as a pancreas-specific autacoid with multiple mechanisms of action and provide unique insight into glucose-stimulated insulin secretion. [Proc Natl Acad Sci U S A]
 
Long-Term In Vitro Human Pancreatic Islet Culture Using Three-Dimensional Microfabricated Scaffolds
Researchers investigated the effects of human islet culture within various three-dimensional environments; collagen I gel, collagen I gel supplemented with extracellular matrix (ECM) components fibronectin and collagen IV, and microfabricated scaffold with ECM-supplemented gel. [Biomaterials]

All-Cause Mortality Trends in a Large Population-Based Cohort with Long-Standing Childhood-Onset Type 1 Diabetes
Although survival has clearly improved, those with diabetes diagnosed most recently (1975-1979) still had a mortality rate 5.6 times higher than that seen in the general population, revealing a continuing need for improvements in treatment and care, particularly for women and African Americans with type 1 diabetes. [Diabetes Care]

Insulin Promoter DNA Methylation Correlates Negatively with Insulin Gene Expression and Positively with HbA1c Levels in Human Pancreatic Islets
The study demonstrates that DNA methylation of the insulin promoter is increased in patients with type 2 diabetes and correlates negatively with insulin gene expression in human pancreatic islets. [Diabetologia]
 
Dissociation of Lipotoxicity and Glucotoxicity in a Mouse Model of Obesity Associated Diabetes: Role of Forkhead Box O1 (FOXO1) in Glucose-Induced Beta Cell Failure
Researchers used a sequential dietary regimen to dissociate the effects of obesity and hyperglycemia on beta cell function and integrity, and to study glucose-induced alterations of key transcription factors over 16 days. [Diabetologia]
 
Co-Immobilization of Urokinase and Thrombomodulin on Islet Surfaces by Poly(Ethylene Glycol)-Conjugated Phospholipid
Researchers propose a versatile method for modifying the surface of islets with the fibrinolytic enzyme urokinase and the soluble domain of the anticoagulant enzyme thrombomodulin. [J Control Release]

PANCREATIC CANCER


Continuous Cell Supply from a Sox9-Expressing Progenitor Zone in Adult Liver, Exocrine Pancreas and Intestine
Researchers show that Sox9 is expressed throughout the biliary and pancreatic ductal epithelia, which are connected to the intestinal stem cell zone. [Nat Genet]

Adaptive Unfolded Protein Response Attenuates Alcohol-Induced Pancreatic Damage
Researchers investigated the role of X box-binding protein 1, an unfolded protein response regulator, in prevention of alcohol-induced endoplasmic reticulum stress in the exocrine pancreas. [Gastroenterology]
 
miR-301a as an NF-KappaB Activator in Pancreatic Cancer Cells
Researchers investigated whether microRNAs (miRNAs) contribute to NF-kappaB activation in pancreatic cancer. They demonstrated that miR-301a down-regulates NF-kappaB-repressing factor and elevates NF-kappaB activation. [EMBO J]

Epithelial Dynamics of Pancreatic Branching Morphogenesis
Results illustrate distinct, step-wise cellular mechanisms by which pancreatic epithelium shapes itself to create a functional branching organ. [Development]
 
Plectin-1 as a Novel Biomarker for Pancreatic Cancer
Plectin-1 is the first biomarker to identify primary and metastatic pancreatic cancer by imaging and may also detect preinvasive PanIN III lesions. [Clin Cancer Res]
 
Ligand Stimulation of ErbB4 and a Constitutively-Active ErbB4 Mutant Result in Different Biological Responses in Human Pancreatic Tumor Cell Lines
Researchers demonstrate that human pancreatic tumor cell lines exhibit minimal ErbB4 expression; in contrast, these cell lines exhibit varied and in some cases abundant expression and basal tyrosine phosphorylation of EGFR, ErbB2, and ErbB3. [Exp Cell Res]

INDUSTRY NEWS

Aetna Launches Diabetes Pilot with Medical Clinic of North Texas to Improve Health Outcomes of Hispanic and African American Patients
Aetna announced a pilot with the Medical Clinic of North Texas aimed at improving the care of diabetic patients of Hispanic and African American descent. [Aetna Inc. Press Release]
 
The NHS Technology Adoption Centre Launches Guide to Redress the Major Inequities Which Exist in the Provision of Diabetes Treatment
The NHS Technology Adoption Centre has launched the How To Why To Guide on Insulin Pump Therapy and believes that this tool can help redress the inequities which currently exist in the treatment of type 1 diabetes. [Business Wire]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)
 
Medicines and Healthcare Products Regulatory Agency (United Kingdom)
 
Therapeutic Goods Administration (Australia)

EVENTS (Listed by Date)

Pharmacology in Stem Cells Research and Regenerative Medicine
December 17, 2010
London, United Kingdom

The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China

Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction
January 12-17, 2011
Dillon, United States

Keystone Symposia: Obesity
January 12-17, 2011
Keystone, United States

2011 Gastrointestinal Cancers Symposium
January 20-22, 2011
San Francisco, United States

Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, D.C., United States

Early Development for Innovative Diabetes & Metabolic Syndrome Therapeutics Conference
January 26-27, 2011
Amsterdam, The Netherlands

Joint Conference of the International Association of Pancreatology and the Indian Pancreas Club
February 10-13, 2011
Maradu, India

2nd Annual International Diabetes Summit
February 22-24, 2011
Dubai, United Arab Emirates

NEW  World Cell Culture Congress 2011
February 28-March 2, 2011
Munich, Germany

NEW PITTCON 2011
March 13-18, 2011
Atlanta, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States

NEW  World Stem Cells & Regenerative Medicine Congress 2011
May 9-11, 2011
London, United Kingdom

13th Annual C21 BioVentures
May 24-26, 2011
Napa, United States

Visit our events page  to stay up to date with the latest events in the cell, gene and immunotherapy community.


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