Volume 1.30 | Nov 16

Pancreatic Cell News 1.30, November 16, 2010.

TOP STORY 

Reversal of Preexisting Hyperglycemia in Diabetic Mice by Acute Deletion of the Men1 Gene  ShareThis
Men1 excision improved glucose metabolism at least partly through increasing proliferation of endogenous beta cells and islet size. [Proc Natl Acad Sci U S A ]

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SCIENCE NEWS

Dietary Changes May Prevent Autoimmunity That Leads to Type 1 Diabetes in At-Risk Babies
Changing the diets of babies with high genetic risk for type 1 diabetes protected them from developing the autoimmunity that destroys insulin-producing cells over the first ten years of life. [Press release from The Hospital for Sick Children discussing online prepublication in the New England Journal of Medicine]
 
Geron Announces Publications Demonstrating That Its Telomerase Inhibitor Drug Targets Cancer Stem Cells
Researchers demonstrate the inhibitory effect of imetelstat on cancer stem cells from breast and pancreatic tumor cell lines in vitro and in animal models of the human disease. [Press release from Geron Corporation discussing online prepublication in Cancer Research]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

DIABETES

Dietary Intervention in Infancy and Later Signs of Beta Cell Autoimmunity
Dietary intervention during infancy appears to have a long-lasting effect on markers of beta cell autoimmunity — markers that may reflect an autoimmune process leading to type 1 diabetes. [N Engl J Med]
 
Three-Amino-Acid-Loop-Extension Homeodomain Factor Meis3 Regulates Cell Survival via PDK1
Researchers show that Meis3 is abundantly expressed in pancreatic islets and beta cells and that it regulates beta cell survival. They further identify the 3-phosphoinositide-dependent protein kinase 1 (PDK1) as a direct Meis3 target, which mediates its role in beta cell survival. [Proc Natl Acad Sci U S A]
 
M3 -Muscarinic Receptor Promotes Insulin Release via Receptor Phosphorylation/Arrestin-Dependent Activation of Protein Kinase D1
Findings support the unique concept that M3-muscarinic receptor-mediated augmentation of sustained insulin release is largely independent of G protein-coupling but involves phosphorylation-/arrestin-dependent coupling of the receptor to protein kinase D1. [Proc Natl Acad Sci U S A]
 
Translationally Controlled Tumor Protein (TCTP) Is a Novel Glucose-Regulated Protein That Is Important for Survival of Pancreatic Beta Cells
Results imply that TCTP levels influence the sensitivity of beta cells to apoptosis. [Diabetologia]
 
Conditional Expression of the FTO Gene Product in Rat INS-1 Cells Reveals Its Rapid Turnover and a Role in the Profile of Glucose-Induced Insulin Secretion
Data suggest that the fat mass and obesity associated (FTO) protein may play a hitherto unrecognized role in the control of first phase insulin secretion in pancreatic beta cells. [Clin Sci]
 
Spontaneous In Vivo Differentiation of Embryonic Stem Cell-Derived Pancreatic Endoderm-Like Cells Corrects Hyperglycemia in Diabetic Mice
Data suggest that Pdx1-expressing pancreatic endoderm-like cells are capable of spontaneously undergoing differentiation in vivo into insulin-producing cells and leading to a sustained correction of hyperglycemia in diabetic mice. [Transplantation]
 
Transforming Growth Factor (TGF)-Beta Induces Epithelial to Mesenchymal Transition and Suppresses the Proliferation and Transdifferentiation of Cultured Human Pancreatic Duct Cells
Results are the first report of TGF-beta1 effects for epithelial to mesenchymal transition and ductal cell transdifferentiation and proliferation at the protein level in human pancreatic duct cells. [J Cell Biochem]

PANCREATIC CANCER


The Telomerase Inhibitor Imetelstat Depletes Cancer Stem Cells in Breast and Pancreatic Cancer Cell Lines
Researchers investigated the effects of imetelstat (GRN163L), a potent telomerase inhibitor, on both the bulk cancer cells and putative cancer stem cells (CSCs). When breast and pancreatic cancer cell lines were treated with imetelstat in vitro, telomerase activity in the bulk tumor cells and CSC subpopulations were inhibited. [Cancer Res]
 
A Migration Signature and Plasma Biomarker Panel for Pancreatic Adenocarcinoma
Results identify a novel 3p pathway associated migration signature and plasma biomarker panel that has utility for discrimination of pancreatic cancer from normal controls and promise for clinical application. [Cancer Prev Res]
 
Cytotoxic Responses to N-(4-Hydroxyphenyl) Retinamide in Human Pancreatic Cancer Cells
Data show that fenretinide triggers pancreatic cancer cell death by apoptosis and autophagy and that sensitivity appears to be mediated by reactive oxygen species and not ceramide. [Cancer Chemother Pharmacol]


INDUSTRY NEWS

Clavis Pharma and Clovis Oncology Extend Partnership and Sign New $205 Million Deal for the Development and Commercialization of Anti-Cancer Agent CP-4126 in Asia and Rest of the World
Clavis Pharma ASA and Clovis Oncology, Inc. announced a new agreement for the further development and commercialization of CP-4126 (also known as CO-101), which is currently in Phase II development in pancreatic cancer. [Clavis Pharma Press Release]
 
London Genetics and Astrimmune to Find Predictive Biomarkers for Pancreatic Cancer Vaccine
London Genetics and Astrimmune will work together to establish a biomarker identification program for the latter’s pancreatic cancer vaccine candidate. [Genetic Engineering and Biotechnology News]
 
Bristol-Myers Squibb Foundation Launches $100 Million Initiative Targeting America’s Type 2 Diabetes Crisis
The Bristol-Myers Squibb Foundation announced Together on Diabetes®: Communities Uniting to Meet America’s Diabetes Challenge, a 5-year, $100 million initiative to help patients living with type 2 diabetes better manage their disease beyond the doors of their doctor’s office — in their homes and communities — and for the course of their disease. [Bristol-Myers Squibb Foundation Press Release]

Xoma Issued Two New U.S. Patents Covering XOMA 052
Xoma Ltd. announced that the U.S. Patent and Trademark Office issued two new patents to Xoma as part of the company’s expanding intellectual property portfolio around its XOMA 052 antibody to interleukin-1 beta. [Xoma Ltd. Press Release]
 
Access Pharmaceuticals Presents CobOral™ Insulin Research at 10th Annual Diabetes Technology Meeting
Access Pharmaceuticals, Inc. announced that it presented a poster at the 10th Annual Diabetes Technology Meeting, entitled, “Preclinical Studies with Cobalamin™ Nanoparticles for Oral Drug Delivery of Insulin.” [Access Pharmaceuticals, Inc. Press Release]

Biodel Reports New Findings from Key Programs at Diabetes Technology Meeting
Scientists from Biodel Inc. reported new findings from the company’s Linjeta™, insulin glargine, “smart” basal insulin and stabilized glucagon development programs in poster presentations at the 10th Annual Diabetes Technology Meeting in Bethesda, MD. [Biodel Inc. Press Release]
 
Halozyme’s rHuPH20 with Recombinant Human Insulin Demonstrates Glycemic Control Comparable to Lispro
Halozyme Therapeutics, Inc. announced Phase II results demonstrating that Insulin-PH20 (recombinant human insulin with rHuPH20) produced glycemic control comparable to lispro. [Halozyme Therapeutics, Inc. Press Release]
 
Biomedical Warp Knit Project Aids Diabetes Research
Narrow fabrics machinery manufacturer Comez has developed an innovative electronic double needle bar warp knitting machine for use in an Italian regional government funded biomedical textiles project. The Panagenesi project aims to help cure diabetes by optimizing the implanting of human pancreatic islands through the use of fibrin scaffold to aid in the success of pancreatic transplants. [Knitting Industry]
 
Boston Scientific Announces Sponsorship of World Diabetes Day Campaign 2010
Boston Scientific Corporation announced its sponsorship of “World Diabetes Day” for the third year in a row.  The campaign is led by the International Diabetes Federation and represents its primary global awareness initiative in the fight against diabetes. [Boston Scientific Corporation Press Release]

POLICY NEWS

Australia Shelves $450 Million Diabetes Care Plan
The federal government has shelved its controversial diabetes reform plan that was meant to allow patients to sign up with a “home” GP practice for continuing care from mid-2012. [Ministry of Health, Australia]

Juvenile Diabetes Research Foundation Clinical Panel Recommends Next Steps for Artificial Pancreas Clinical Testing
Diabetes experts at a meeting convened by the U.S. Food and Drug Administration and the National Institutes of Health took the next step in advancing efforts toward the development of an artificial pancreas: putting forth clinical recommendations to ensure the safe and effective testing of artificial pancreas technology in real-life situations. [Juvenile Diabetes Research Foundation, United States]
 
FDA Seen Tougher on Drug Risks Post-Avandia
Regulators appear to be increasing their scrutiny of product risks after cases like the bitter debate over the diabetes pill Avandia, industry executives and experts said. [Food and Drug Administration, United States]

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EVENTS (Listed by Date)

Pharmacology in Stem Cells Research and Regenerative Medicine
December 17, 2010
London, United Kingdom

NEW The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China

Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction
January 12-17, 2011
Dillon, United States

Keystone Symposia: Obesity
January 12-17, 2011
Keystone, United States

2011 Gastrointestinal Cancers Symposium
January 20-22, 2011
San Francisco, United States

Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, D.C., United States

Early Development for Innovative Diabetes & Metabolic Syndrome Therapeutics Conference
January 26-27, 2011
Amsterdam, The Netherlands

Joint Conference of the International Association of Pancreatology and the Indian Pancreas Club
February 10-13, 2011
Maradu, India

NEW 2nd Annual International Diabetes Summit
February 22-24, 2011
Dubai, United Arab Emirates

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States

13th Annual C21 BioVentures
May 24-26, 2011
Napa, United States

European Pancreatic Club Meeting 2011
June 22-25, 2011
Magdeburg, Germany

PancreasFest 2011
July 28-30, 2011
Pittsburgh, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

 


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