Volume 1.26 | Oct 19

Pancreatic Cell News 1.26, October 19, 2010.

TOP STORY 

Enterovirus RNA in Blood Is Linked to the Development of Type 1 Diabetes  ShareThis
The present study supports the hypothesis that enteroviruses play a role in the pathogenesis of type 1 diabetes, especially in the initiation of the beta cell damaging process. [Diabetes]

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SPECIAL FEATURE 

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SCIENCE NEWS

Better Drug Delivery Eradicates Tumors
A new study demonstrates further promise for chitosan/interleukin-12 as an effective anti-tumor immunotherapy. Findings revealed that injections of chitosan/IL-12 eradicated aggressive colorectal and pancreatic tumors. [Press release from the University of Arkansas discussing online prepublication in the Journal of Immunotherapy]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

DIABETES

The Dicarboxylate Carrier Plays a Role in Mitochondrial Malate Transport and in the Regulation of Glucose-Stimulated Insulin Secretion from Rat Pancreatic Beta Cells
Malate transport by dicarboxylate carrier may play an important role in glucose-stimulated insulin secretion, possibly by providing cytosolic malate as a counter-substrate for citrate and/or isocitrate export by citrate/isocitrate carrier. [Diabetologia]

AMP-Activated Protein Kinase (AMPK) Regulates Glucagon Secretion from Mouse Pancreatic Alpha Cells
AMPK is strongly regulated by glucose in pancreatic alpha cells, and increases in AMPK activity are sufficient and necessary for the stimulation of glucagon release in vitro. [Diabetologia]
 
Glucose Stimulates Human Beta Cell Replication In Vivo in Islets Transplanted into Non-Obese Diabetic-Severe Combined Immunodeficiency Mice
Researchers determined whether hyperglycemia stimulates human beta cell replication in vivo in an islet transplant model. [Diabetologia]

Genetic Analysis of Type-1 Insulin-Like Growth Factor Receptor Signaling Through Insulin Receptor Substrate-1 and -2 in Pancreatic Beta Cells
Researchers conclude that IGF1 receptor signals primarily through Irs1 and affects insulin secretion, whereas beta cell proliferation is mainly regulated by inactivation of insulin receptor using Irs2 as a downstream signaling effector. The insulin and IGF pathways appear to control beta cell functions independently and selectively. [J Biol Chem]
 
Calcineurin Signaling Regulates Human Islet Beta Cell Survival
Findings reveal calcineurin as a regulator of human beta cell survival in part through regulation of insulin receptor substrate-2, with implications for the pathogenesis and treatment of diabetes following organ transplantation. [J Biol Chem]
 
Inhibition of the Nuclear Factor-KappaB Pathway Prevents Beta Cell Failure and Diet Induced Diabetes in Psammomys obesus
Inhibition of inhibitor kinase beta activity prevents diet-induced diabetes in P. obesus and inhibits IL-1beta induced reactive oxygen species, loss of insulin production and beta cell death in vitro. [PLoS ONE]
 
EuroDia: A Beta Cell Gene Expression Resource
The EuroDia database has been established to build a unique collection of gene expression measurements performed on beta cells of three organisms, namely human, mouse and rat. The Gene Expression Data Analysis Interface has been developed to support this database. [Database]

PANCREATIC CANCER

PRSS3 Promotes Tumor Growth and Metastasis of Human Pancreatic Cancer
The effect of PRSS3 on cancer cell proliferation, migration and invasion in vitro, tumor growth and metastasis in vivo were investigated by manipulation of PRSS3 expression in human pancreatic cancer cell lines. [Gut]
 
TRAIL-Induced Apoptosis Is Preferentially Mediated via TRAIL Receptor 1 in Pancreatic Carcinoma Cells and Profoundly Enhanced by XIAP Inhibitors
Mapatumumab exerts antitumor activity especially in combination with XIAP inhibitors against most pancreatic carcinoma cell lines, while Lexatumumab requires crosslinking for optimal cytotoxity. [Clin Cancer Res]
 
Rho-Kinase Signaling Regulates Trypsinogen Activation and Tissue Damage in Severe Acute Pancreatitis
Data suggest that Rho-kinase signaling plays an important role in acute pancreatitis by regulating trypsinogen activation and subsequent CXC chemokine formation, neutrophil infiltration and tissue injury. [Br J Pharmacol]
 
A Novel Protein Kinase D Inhibitor Attenuates Early Events of Experimental Pancreatitis in Isolated Rat Acini
CRT0066101 is a potent and specific protein kinase D (PKD/PKD1) family inhibitor. Further, PKD/PKD1 is a potential mediator of zymogen activation, amylase secretion, and NF-kappaB activation induced by a range of secretagogues in pancreatic acinar cells. [Am J Physiol Gastrointest Liver Physiol]
 
Intratumoral Immunotherapy of Established Solid Tumors with Chitosan/IL-12
Antitumor efficacy of IL-12 alone and IL-12 coformulated with chitosan was assessed in mice bearing established colorectal and pancreatic tumors. [J Immunother]

INDUSTRY NEWS

Kuwait’s Dasman Diabetes Institute Signs Agreement with The Forsyth Institute
In the face of a dramatic worldwide increase in adolescent obesity and type 2 diabetes, The Forsyth Institute announced a research alliance with the Dasman Diabetes Institute of Kuwait to initiate studies that could lay a scientific basis for prevention. This collaboration, called The Kuwait Healthy Life Study, will examine conditions in children that predispose them to obesity and Type 2 diabetes. [The Forsyth Institute Press Release]

Rice, Texas Medical Center Team Take Aim at Pancreatic Cancer
Researchers from Rice University’s Laboratory for Nanophotonics, the radiology department at Baylor College of Medicine and the University of Texas MD Anderson Cancer Center are preparing to test a combined approach for diagnosing and treating pancreatic cancer with a specially engineered nanoparticle. [Rice University Press Release]
 
Biocon and Pfizer Enter into Global Commercialization Agreement
Biocon and Pfizer Inc. announced that they have entered into a strategic global agreement for the worldwide commercialization of Biocon’s biosimilar versions of Insulin and Insulin analog products: Recombinant Human Insulin, Glargine, Aspart and Lispro. [Pfizer Inc. Press Release]
 
Sanofi-aventis Establishes Research Collaboration with Harvard University
Sanofi-aventis announced a research collaboration with Harvard University. The goal of the collaboration is to advance knowledge in the area of human health through basic and applied research and to promote scientific exchange between Harvard University and Sanofi-aventis. [Sanofi-aventis Press Release]

$3.7 Million to Push Cancer Discoveries Down the ‘Pipeline’
The Cancer Institute New South Wales has awarded the Garvan Institute’s Cancer Research Program $3.7 million, research funding that should lead to improved clinical decision-making for breast, prostate and pancreatic cancer within the next 5 years. [The Garvan Institute Press Release]
 
DiaMedica Announces Positive Final Results in Type 1 Diabetes Study
DiaMedica Inc., is pleased to announce positive final results from its previously announced type 1 diabetes study. The study was designed to observe the potential protective and/or regenerative effects on beta cells in a widely accepted type 1 diabetes animal model. [DiaMedica Inc. Press Release]

POLICY NEWS

IQWiG: Law Must Prescribe Obligation to Publish All Clinical Trials
If the currently discussed draft on the “Law on the Reorganization of the Pharmaceutical Market” (AMNOG) is implemented, drug manufacturers will in future have to register their clinical trials at inception and publish results after completion. [Institute for Quality and Efficiency in Health Care (IQWiG), Germany]

Innovations in Technology for the Treatment of Diabetes: Clinical Development of the Artificial Pancreas (an Autonomous System); Public Workshop (FR Doc. 2010-25600) [Food and Drug Administration, United States]

Draft Guidance for Industry: Early Clinical Trials With Live Biotherapeutic Products: Chemistry, Manufacturing, and Control Information; Availability (FR Doc. 2010-25850) [Food and Drug Administration, United States]
 
Draft Guidance for Industry on Investigational New Drug Applications–Determining Whether Human Research Studies Can Be Conducted Without an Investigational New Drug Application; Availability (FR Doc. 2010-25851) [Food and Drug Administration, United States]
 
National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings (FR Doc. 2010-26031) [National Institutes of Health, United States]
 
National Institute of Diabetes and Digestive and Kidney Diseases; Amended Notice of Meeting (FR Doc. 2010-26183) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26028) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26033) [National Institutes of Health, United States]
 
National Cancer Institute; Notice of Meeting (FR Doc. 2010-26032) [National Institutes of Health, United States]
 
National Cancer Institute; Notice of Closed Meetings (FR Doc. 2010-26035) [National Institutes of Health, United States]
 
Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-26036) [National Institutes of Health, United States] 

EVENTS (Listed by Date)

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

2010 American Pancreatic Association (APA) Annual Meeting
November 3-6, 2010
Chicago, United States

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

Australasian Pancreatic Club Annual Meeting
November 15-16, 2010
Melbourne, Australia

Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction
January 12-17, 2011
Dillon, United States

Keystone Symposia: Obesity
January 12-17, 2011
Keystone, Colorado

2011 Gastrointestinal Cancers Symposium
January 20-22, 2011
San Francisco, United States

Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, DC, United States

NEW Early Development for Innovative Diabetes & Metabolic Syndrome Therapeutics Conference
January 26-27, 2011
Amsterdam, The Netherlands

Joint Conference of the International Association of Pancreatology and the Indian Pancreas Club
February 10-13, 2011
Maradu, India

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

 

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