Volume 1.20 | Sep 7

Pancreatic Cell News 1.20, September 7, 2010.


TOP STORY 

Pcif1 Modulates Pdx1 Protein Stability and Pancreatic Beta Cell Function and Survival in Mice  ShareThis
Findings indicate that in adult mouse beta cells, Pdx1 C terminus-interacting factor-1 (Pcif1) limits pancreatic duodenal homeobox 1 (Pdx1) protein accumulation and thus the expression of insulin and other gene targets important in the maintenance of beta cell mass and function. [J Clin Invest]

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SCIENCE NEWS

Researchers Use iPSCs to Create Rat Pancreas Inside Body of Mouse
A Japanese research team has succeeded in creating a rat pancreas inside the body of a mouse using induced pluripotent stem cells (iPSCs). [Press release from The Mainichi Daily News discussing online prepublication in Cell]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

DIABETES

Generation of Rat Pancreas in Mouse by Interspecific Blastocyst Injection of Pluripotent Stem Cells
Mouse wild-type pluripotent stem cells (PSCs) injected into Pdx1-/- (pancreatogenesis-disabled) mouse blastocysts developmentally compensated vacancy of the pancreatic “developmental niche,” generating an almost entirely PSC-derived pancreas. [Cell]
 
Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist Stimulates Insulin Secretion in Rodents and from Human Islets
The studies characterize the insulinotropic effects of an early-stage, small molecule glucagon-like peptide-1 receptor agonist and provide compelling evidence to support pharmaceutical optimization. [Diabetes]

Insulin Reciprocally Regulates Glucagon Secretion in Humans
Researchers document that insulin is a beta cell secretory product that, in concert with glucose and among other signals, reciprocally regulates alpha cell glucagon secretion in humans. [Diabetes]

Human-IAPP Disrupts the Autophagy/Lysosomal Pathway in Pancreatic Beta Cells: Protective Role of p62-Positive Cytoplasmic Inclusions
Researchers report that increased expression of human-islet amyloid polypeptide (IAPP) led to impaired autophagy, due at least in part to the disruption of lysosome-dependant degradation. [Cell Death Differ]

Declining Beta Cell Function Relative to Insulin Sensitivity With Increasing Fasting Glucose Levels in the Nondiabetic Range in Children
The impairment in beta cell function relative to insulin sensitivity is apparent even within the nondiabetic fasting plasma glucose range in children. [Diabetes Care]

Common Genetic Variation in GLP1R and Insulin Secretion in Response to Exogenous GLP-1 in Nondiabetic Subjects
Variation in GLP1R may alter insulin secretion in response to exogenous glucagon-like peptide (GLP)-1. [Diabetes Care]

Neonatal Diabetes Caused by Mutations in Sulfonylurea Receptor 1: Interplay between Expression and Mg-Nucleotide Gating Defects of ATP-Sensitive Potassium Channels
Results demonstrate that E208K and V324M, located in distinct domains of SUR1, enhance transduction of Mg-nucleotide stimulation from the SUR1 nucleotide binding folds to Kir6.2. [J Clin Endocrinol Metab]

PANCREATIC CANCER

PTEN Loss Accelerates KrasG12D-Induced Pancreatic Cancer Development
Data support a dosage-dependent role for PTEN, and the resulting dysregulation of the PI3K/AKT signaling axis, in both pancreatic ductal adenocarcinoma initiation and progression, and shed additional light on the signaling mechanisms that lead to the development of acinar-to-ductal metaplasia and subsequent malignant pancreatic intraepithelial neoplasia and pancreatic cancer. [Cancer Res]

Gli3 Mediates Cell Survival and Sensitivity to Cyclopamine in Pancreatic Cancer
Knockdown of GLI3 using siRNAs increased sensitivity to cyclopamine. In addition, GLI3 siRNAs decreased pancreatic adenocarcinoma cell viability and reduced expression of genes involved in hedgehog signaling (Patched 1 and GLI1) and cell proliferation, similar to cyclopamine. [Cancer Biol Ther]

The Role of Autophagy in the Treatment of Pancreatic Cancer with Gemcitabine and Ionizing Radiation
Results suggest that autophagy can be activated by gemcitabine and/or ionizing radiation in the treatment of pancreatic cancer cells and that activated autophagy plays a role in cancer suppression. [Int J Oncol]


INDUSTRY NEWS

Concordia Pharmaceuticals, Inc. Signs First Licensing Agreement with Ono Pharmaceutical Co, Ltd. for Salirasib
Concordia Pharmaceuticals, Inc. announced that it has signed a licensing agreement with Ono Pharmaceutical Co, Ltd. (Osaka, Japan) for salirasib, a first-in-class, targeted agent for the treatment of pancreatic, non-small cell lung and colorectal cancers. [Concordia Pharmaceuticals, Inc. Press Release]

Forbion Capital Partners Raises EUR190 Million for New Investments
Forbion Capital Partners, a leading investment firm dedicated to the life science sector, announced the final closings of both FCF I Co-Invest Fund and of FCF II, raising a total of more than EUR190 million ($240 million). [Forbion Capital Partners Press Release]

Trial to Test Experimental Drug for Advanced Pancreatic Cancer
Cancer Research UK’s Drug Development Office has launched a clinical trial to test an experimental drug in patients with advanced (Stage IV) pancreatic cancer. [Cancer Research UK Press Release]

Halozyme Begins Phase II Clinical Trials with Insulin Analogs Lispro and Aspart with rHuPH20 in Type 1 and Type 2 Diabetes
Halozyme Therapeutics, Inc. announced the initiation of two Phase II Ultrafast Insulin treatment studies that utilize its rHuPH20 hyaluronidase enzyme (PH20) in combination with the two leading commercially available mealtime analogs: insulin aspart, the active ingredient in NovoLog®, and insulin lispro, the active ingredient in Humalog®. [Halozyme Therapeutics, Inc. Press Release]

POLICY NEWS

Obama Administration Appeals Stem Cell Injunction
The Obama administration appealed a ruling that blocked federal funding of embryonic stem cell research and asked the judge who issued the injunction to put it on hold pending the appeal. [Administration, United States]

FDA Launches New Organizational Performance Management System
The U.S. Food and Drug Administration (FDA) launched an innovative performance management system designed to advance the President’s commitment to transparency, public participation, and collaboration in the work of government. [Food and Drug Administration, United States]

NIH Asks Judge to Suspend Stem Cell Research Injunction
Warning of a “devastating impact” on ongoing research, the National Institutes of Health (NIH) asked a federal court to stay a preliminary injunction that forced NIH to suspend future grant payments to study human embryonic stem cells (hESC) and shut down its in-house research on hESCs. [National Institutes of Health, United States]

NIH Awards Grants to Support Biomedical Research in Space
The National Institutes of Health (NIH) announced that it has awarded the first new grants under the Biomedical Research on the International Space Station (BioMed-ISS) initiative, a collaborative effort between NIH and NASA. [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-22096) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-22120) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-22128) [National Institutes of Health, United States]
 
Center for Scientific Review; Amended Notice of Meeting (FR Doc. C1-2010-22119) [National Institutes of Health, United States]
 
Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting (FR Doc. 2010-22107)  [National Institutes of Health, United States]
 
National Cancer Institute; Notice of Closed Meetings (FR Doc. 2010-22093) [National Institutes of Health, United States]
 
National Human Genome Research Institute; Notice of Closed Meeting (FR Doc. 2010-21819) [National Institutes of Health, United States] 

EVENTS (Listed by Date)

The Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland (AUGIS) 2010 Scientific Meeting 
September 9-10, 2010
Oxford, United Kingdom

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States 

Annual Human Proteome Organization (HUPO) World Congress
September 19-23, 2010
Sydney, Australia

46th European Association for the Study of Diabetes Annual Meeting
September 20-24, 2010
Stockholm, Sweden

Institute of Medicine – University of Illinois at Chicago Midwest Conference on Diabetes and Obesity
September 21, 2010
Chicago, United States

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

Fraunhofer Life Science Symposium 2010
October 29-30, 2010
Leipzig, Germany

2010 American Pancreatic Association (APA) Annual Meeting
November 3-6, 2010
Chicago, United States

Select Biosciences International Forum on Stem Cells
November 12-13, 2010
Tianjin, China

Australasian Pancreatic Club Annual Meeting
November 15-16, 2010
Melbourne, Australia

Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction
January 12-17, 2011
Keystone, United States

2011 Gastrointestinal Cancers Symposium
January 20-22, 2011
San Francisco, United States

Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

Select Biosciences 5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, DC, United States

Joint Conference of the International Association of Pancreatology and the Indian Pancreas Club
February 10-13, 2011
Maradu, India

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

 

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