Volume 1.19 | Aug 31

Pancreatic Cell News 1.19, August 31, 2010.


TOP STORY 

Nuclear Hormone Receptor RXR Negatively Regulates the Glucose-Stimulated Insulin Secretion of Pancreatic Beta Cells  ShareThis
Results suggest that endogenous retinoid X receptors (RXR) negatively regulates glucose-stimulated insulin secretion. [ Diabetes]

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SCIENCE NEWS

Insulin Users Have 50% Higher Cancer Risk; Causes Are Unclear, Study Says
Diabetics who take insulin have a higher risk of developing cancer, according to Danish researchers who say they can’t explain the link. Patients on insulin were 50 percent more likely to get cancer compared with the general population. [Press release from Bloomberg discussing online presentation abstract for the European Association for the Study of Diabetes]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

DIABETES

Glycemia Determines the Effect of Type 2 Diabetes Risk Genes on Insulin Secretion
For the diabetes risk genes TCF7L2 and WFS1, which are associated with impaired incretin signaling, the level of glycemia determines SNP effects on insulin secretion. [Diabetes]

Angiotensin-I Converting Enzyme Type 2 (ACE2) Gene Therapy Improves Glycemic Control in Diabetic Mice
Findings identify ACE2 as a novel target for the prevention of beta cell dysfunction and apoptosis occurring in type 2 diabetes. [Diabetes]

Mcl-1 Downregulation by Pro-Inflammatory Cytokines and Palmitate Is an Early Event Contributing to Beta Cell Apoptosis
Data suggest that Mcl-1 downregulation is a crucial event leading to beta cell apoptosis and provide new insights into the mechanisms linking endoplasmic reticulum stress and the mitochondrial intrinsic pathway of apoptosis. [Cell Death Differ]

Immobilization of the Soluble Domain of Human Complement Receptor 1 on Agarose-Encapsulated Islets for the Prevention of Complement Activation
Researchers aimed to develop a bioartificial pancreas that can realize xeno-islet transplantation. [Biomaterials]

Transamination Is Required for Alpha-Ketoisocaproate (KIC) but not Leucine to Stimulate Insulin Secretion
KIC and leucine-stimulated insulin secretion occur by enhancing the metabolism of glutamine/glutamate to alpha-ketoglutarate, which in turn is metabolized to produce the intracellular signals such as ATP and NADPH for insulin secretion. [J Biol Chem]
 
The Chaperone Proteins HSP70, HSP40/DnaJ, and GRP78/BiP Suppress Misfolding and Formation of Beta-Sheet-Containing Aggregates by Human Amylin: A Potential Role for Defective Chaperone Biology in Type 2 Diabetes
Defective beta cell chaperone biology could contribute to human amylin-misfolding and initiation of apoptosis in type 2 diabetes. [Biochem J]

Diabetes and Insulin Duration and Cancer Incidence: A Register Linkage Study in Denmark
Researchers found that patients on insulin carry an extra risk of cancer, in the order of magnitude of 50% relative to the general population. [European Association for the Study of Diabetes]

PANCREATIC CANCER

Pancreatic Adenocarcinoma Upregulated Factor Promotes Metastasis by Regulating TLR/CXCR4 Activation
Findings suggest that the new cancer-associated ligand, pancreatic adenocarcinoma upregulated factor (PAUF), may activate Toll-like receptor (TLR)-mediated extracellular signal-regulated kinase signaling to produce the protumorigenic cytokines, but inhibits TLR-mediated nuclear factor-kappaB signaling, thereby facilitating tumor growth and escape from innate immune surveillance. [Oncogene]
 
Aberrant Overexpression of the RGL2 Ral Small GTPase-Specific Guanine Nucleotide Exchange Factor Promotes Pancreatic Cancer Growth Through Ral-Dependent and -Independent Mechanisms
Observations support nonredundant roles for RalGEFs in Ras-mediated oncogenesis and a key role for Rgl2 in Ral activation and Ral-independent pancreatic ductal adenocarcinoma growth. [J Biol Chem]
 
Identification and Characterization of a Tumor Infiltrating CD56+/CD16- NK Cell Subset with Specificity for Pancreatic and Prostate Cancer Cell Lines
Researchers identified a unique subset of NK cells (CD56brightCD16dim) isolated from a regressing metastatic pancreatic cancer in a patient responding to Ipilimumab. [Cancer Immunol Immunother]

CCK-Independent mTORC1 Activation During Dietary Protein-Induced Exocrine Pancreas Growth
Prolonged mTORC1 activation is required for dietary protein-induced pancreatic growth in the absence of CCK. [Am J Physiol Gastrointest Liver Physiol]

INDUSTRY NEWS

Roche and Aileron Enter Multi-target Alliance to Develop Stapled Peptide Drugs for Diseases across Multiple Therapeutic Areas
Aileron Therapeutics and Roche announced that they have entered into a collaboration to discover, develop and commercialize a new class of drugs called Stapled Peptide Therapeutics. [Aileron Therapeutics Press Release]

Sanofi-aventis Announces Non-Binding Offer to Acquire Genzyme
Sanofi-aventis announced that it has submitted a non-binding proposal to acquire Genzyme in an all-cash transaction valued at approximately $18.5 billion. [Sanofi-aventis Press Release]

Genzyme Confirms Receipt of Unsolicited Proposal
Genzyme Corp. confirmed that it has received an unsolicited, non-binding proposal from Sanofi-aventis to acquire all the outstanding shares of Genzyme for $69 per share in cash. The Genzyme board of directors unanimously affirmed its previous rejection of Sanofi’s proposal. [Genzyme Press Release]

Biodel to Raise $9.4 Million Through Registered Direct Offering
Biodel Inc. announced that it has entered into definitive agreements with two institutional investors to sell 2,398,200 shares of its common stock and warrants to purchase 2,398,200 shares of its common stock. [Biodel Inc. Press Release]

Study Links Actos to Heart Risks
Actos, the top-selling diabetes drug, causes as many heart problems as Avandia, the pill whose sales tumbled after it was linked to higher heart-disease rates, a study found. [The Boston Globe]

MannKind Corporation Providing AFREZZA™ to Juvenile Diabetes Research Foundation for Artificial Pancreas Project
MannKind Corporation announced that the company will supply its novel, ultra rapid acting insulin AFREZZA™ (insulin human [rDNA origin]) for use in a study being conducted by the Juvenile Diabetes Research Foundation as part of its Artificial Pancreas Project. [MannKind Corporation Press Release]

POLICY NEWS

The American Diabetes Association Decries New Barrier to Embryonic Stem Cell Research
The American Diabetes Association is extremely disappointed by the federal district court decision blocking the federal government from funding research involving embryonic stem cells. [American Diabetes Association, United States]

NIH Orders Immediate Shutdown of Intramural Human Embryonic Stem Cell Research
Responding to a court order, the National Institutes of Health (NIH) ordered intramural researchers studying human embryonic stem cells to shut down their experiments. [National Institutes of Health, United States]

Request for Comments on Synthetic Biology (FR Doc. 2010-21359) [Department of Health and Human Services, United States]

Notice of Meeting: Secretary’s Advisory Committee on Genetics, Health, and Society (FR Doc. 2010-21532) [Department of Health and Human Services, United States]

National Institute of Diabetes and Digestive and Kidney Diseases Centers for Diabetes Translation Research (P30) (RFA-DK-10-009) [National Institute of Diabetes and Digestive and Kidney Diseases, United States]

National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings (FR Doc. 2010-21090) [National Institutes of Health, United States]

NIH Director’s Response to Stem Cell Injunction [National Institutes of Health, United States]

Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-20861) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-21357) [National Institutes of Health, United States]

National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-21282) [National Institutes of Health, United States]
 
National Center for Research Resources; Notice of Closed Meeting (FR Doc. 2010-21280) [National Institutes of Health, United States]
 
Public Workshop on Cell and Gene Therapy Clinical Trials in Pediatric Populations [Center for Biologics Evaluation and Research, Untied States]
 
Guidance for Industry: Electronic Submission of Lot Distribution Reports for Biological Products [Center for Biologics Evaluation and Research, Untied States]

Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical Practice; Public Workshop [FR Doc. 2010-20834] [Food and Drug Administration, United States]

EVENTS (Listed by Date)

The European Molecular Biology Organization (EMBO) Meeting – Advancing the Life Sciences
September 4-7, 2010
Barcelona, Spain

The Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland (AUGIS) 2010 Scientific Meeting 
September 9-10, 2010
Oxford, United Kingdom

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States 

Annual Human Proteome Organization (HUPO) World Congress
September 19-23, 2010
Sydney, Australia

NEW 46th European Association for the Study of Diabetes Annual Meeting
September 20-24, 2010
Stockholm, Sweden

Institute of Medicine – University of Illinois at Chicago Midwest Conference on Diabetes and Obesity
September 21, 2010
Chicago, United States

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

Fraunhofer Life Science Symposium 2010
October 29-30, 2010
Leipzig, Germany

2010 American Pancreatic Association (APA) Annual Meeting
November 3-6, 2010
Chicago, United States

Select Biosciences International Forum on Stem Cells
November 12-13, 2010
Tianjin, China

Australasian Pancreatic Club Annual Meeting
November 15-16, 2010
Melbourne, Australia

Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction
January 12-17, 2011
Dillon, United States

2011 Gastrointestinal Cancers Symposium
January 20-22, 2011
San Francisco, United States

Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

Select Biosciences 5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, DC, United States

Joint Conference of the International Association of Pancreatology and the Indian Pancreas Club
February 10-13, 2011
Maradu, India

Visit our events page  to stay up to date with the latest events in the cell, gene and immunotherapy community.

 

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