Volume 1.15 | Aug 3

Pancreatic Cell News 1.15, August 3, 2010.


TOP STORY 

One Molecule, Many More Insulin-Producing Cells to Treat Diabetes  ShareThis
With a single stimulatory molecule, human insulin-producing beta cell replication can be sustained for at least four weeks in a mouse model of diabetes, according to researchers. [Press release from the University of Pittsburgh School of Medicine discussing online prepublication in Diabetes]

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SCIENCE NEWS

Pancreatic Cancers Use Fructose, Common in a Western Diet, to Fuel Growth
Pancreatic cancers use the sugar fructose to activate a key cellular pathway that drives cell division, helping the cancer to grow more quickly. [Press release from the University of California, Los Angeles Jonsson Comprehensive Cancer Center discussing online prepublication in Cancer Research]

Bacteriolytic Therapy May Be a Promising Treatment Strategy for Advanced Pancreatic Cancer Patients
Data indicate that the application of bacteria may be a promising treatment strategy for patients with advanced pancreatic cancer and warrants further investigation. [Press release from ScienceDaily discussing online prepublication in the World Journal of Gastroenterology]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

DIABETES

Induction of Human Beta Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6
A single molecule, cdk6, proved to be capable of driving human beta cell replication in vitro and enhancing human islet engraftment/proliferation in vivo, superior to normal islets and as effectively as the combination of cdk6 plus a D-cyclin. [Diabetes]

INS-1 Cells Undergoing Caspase-Dependent Apoptosis Enhance the Regenerative Capacity of Neighbouring Cells
Results suggest that apoptosing INS-1 cells shed microparticles that may stimulate PSP/reg induction in neighboring cells, a mechanism that may facilitate the recovery of beta cell mass in HNF1A-maturity-onset-diabetes-of-the-young. [Diabetes]

Activation of Pancreatic-Duct-Derived Progenitor Cells During Pancreas Regeneration in Adult Rats
Researchers provide a mechanism by which adult pancreatic duct cells recapitulate aspects of embryonic pancreas differentiation in response to injury, and contribute to regeneration of the pancreas. [J Cell Sci]

B1 Cells Promote Pancreas Infiltration by Autoreactive T Cells
Data identify a role for B1 cells in permitting circulating islet-specific T cells to access their Ag-bearing tissue and emphasize the existence of multiple checkpoints to regulate autoimmune disease. [J Immunol]

A Novel Role for the Centrosomal Protein, Pericentrin, in Regulation of Insulin Secretory Vesicle Docking in Mouse Pancreatic Beta Cells
Researchers observed abundant expression of pericentrin in quiescent pancreatic beta cells of normal animals which led them to hypothesize that pericentrin may have a critical function in beta cells distinct from its known role in regulating cell cycle progression. [PLoS One]

PANCREATIC CANCER

Nanoconjugation Modulates the Trafficking and Mechanism of Antibody Induced Receptor Endocytosis
Researchers demonstrate that the distinct patterning and dynamics of anti-EGFR (epidermal growth factor receptor) antibody cetuximab-induced EGFR internalization in pancreatic cancer cells with variable receptor expression is altered upon nanoconjugation. [Proc Natl Acad Sci U S A]

Fructose Induces Transketolase Flux to Promote Pancreatic Cancer Growth
Researchers report that fructose provides an alternative substrate to induce pancreatic cancer cell proliferation. [Cancer Res]

MEK Inhibition Potentiates the Activity of Hsp90 Inhibitor 17-AAG against Pancreatic Cancer Cells
Data demonstrate that MEK inhibitor U0126 potentiates the activity of Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin against pancreatic cancer cells. [Mol Pharm]

The miR-217 MicroRNA Functions as a Potential Tumor Suppressor in Pancreatic Ductal Adenocarcinoma by Targeting KRAS
Researchers conclude that the frequently downregulated miR-217 can regulate KRAS and function as a tumor suppressor in pancreatic ductal adenocarcinoma. [Carcinogenesis]

Nitric Oxide Inhibits the Proliferation and Invasion of Pancreatic Cancer Cells through Degradation of Insulin Receptor Substrate-1 Protein
Findings indicate that nitric oxide inhibits the proliferation and invasion of pancreatic cancer cells, at least in part, through upregulation of insulin receptor substrate-1 protein degradation and resultant downregulation of the insulin/insulin-like growth factor-I-Akt pathway. [Mol Cancer Res]

Bacteriolytic Therapy of Experimental Pancreatic Carcinoma
The observed complete tumor regression is encouraging and shows that immunotherapy with Clostridium novyi-NT is an interesting strategy for the treatment of pancreatic carcinomas of defined sizes. [World J Gastroenterol]



INDUSTRY NEWS

Sanofi-aventis Said to Be Likely to Bid $18 Billion for Genzyme
Sanofi-aventis is likely to make an unsolicited offer of up to $70 a share for Genzyme, raising the stakes for what could become one of the year’s biggest deals, people briefed on the matter said. [The New York Times]

British Companies to Receive Support to Develop New Regenerative Medicine Products and Technologies
The government-backed Technology Strategy Board is to invest over £5 million to support the research and development in the UK of new regenerative medicine products, tools and technologies. 16 research and development projects in the field of regenerative medicine therapeutics are to receive a total of £3.6 million of investment, while a further £1.6 million is to be invested in 12 feasibility studies in the area of regenerative medicine tools and technologies. [Technology Strategy Board Press Release]

Immune Design Corporation Raises $32 Million in Series B Financing
Immune Design Corporation announced that it has secured $32 million in Series B financing. [PR Newswire]



POLICY NEWS

Government of Canada Announces Continued Support of National Aboriginal Diabetes Initiative
The Minister of Health announced $110 million in funding over two years for the Aboriginal Diabetes Initiative to continue addressing high rates of diabetes among Aboriginal people. [Aboriginal Diabetes Initiative, Canada]

NSF Funding Request Faring Well in Congress
While the 2011 budget requests of other U.S. research agencies are struggling to stay afloat in choppy fiscal seas, so far National Science Foundation’s (NSF) is sailing through Congress largely intact. [National Science Foundation, United States]

Senate Spending Panel Approves $1 Billion Boost for NIH
A Senate subcommittee matched President Barack Obama’s request for a $1 billion increase in 2011 for the National Institutes of Health (NIH). That raise would bring the agency’s total budget to $32 billion, or 3.5% above the 2010 level, according to a statement from the Senate appropriations labor, health, and human services subcommittee. [National Institutes of Health, United States]

Risk Evaluation and Mitigation Strategy (REMS) Public Meeting
The Food and Drug Administration announced a 2-day public meeting to obtain input on issues and challenges associated with the development and implementation of risk evaluation and mitigation strategies for drugs. An archived webcast of the meeting is available. [Food and Drug Administration, United States]

MHRA Business Plan 2010 and Corporate Plan 2010-15 Published
The MHRA gained ministerial agreement for the Agency’s Business Plan 2010 and the Corporate Plan 2010-15. [Medicines and Healthcare Products Regulatory Agency, United Kingdom]

Agency Information Collection Activities: Proposed Collection; Comment Request [Agency for Healthcare Research and Quality, United States]

National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meeting [National Institute of Diabetes and Digestive and Kidney Diseases, United States]

Change of Application Budget Limit for NIDDK PAR-08-182: Collaborative Interdisciplinary Team Science in Diabetes, Endocrinology and Metabolic Diseases (R24) (NOT-DK-10-011) [National Institute of Diabetes and Digestive and Kidney Diseases, United States]

National Cancer Institute; Notice of Closed Meetings [National Institutes of Health, United States]

Office of the Director; Notice of Closed Meeting [National Institutes of Health, United States]

National Institute of Biomedical Imaging and Bioengineering; Notice of Meeting [National Institutes of Health, United States]

Correction of Major Programmatic Priorities for RFA-HL-11-025 (R01); “New Strategies for Growing 3D Tissues” (NOT-HL-11-115) [National Institutes of Health, United States]




EVENTS (Listed by Date)

2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences 2nd Annual World Biobanking Summit
August 24-25, 2010
Edinburgh, Scotland

The European Molecular Biology Organization (EMBO) Meeting – Advancing the Life Sciences
September 4-7, 2010
Barcelona, Spain

The Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland (AUGIS) 2010 Scientific Meeting 
September 9-10, 2010
Oxford, United Kingdom

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States 

Annual Human Proteome Organization (HUPO) World Congress
September 19-23, 2010
Sydney, Australia

Institute of Medicine – University of Illinois at Chicago Midwest Conference on Diabetes and Obesity
September 21, 2010
Chicago, United States

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

Fraunhofer Life Science Symposium 2010
October 29-30, 2010
Leipzig, Germany

2010 American Pancreatic Association (APA) Annual Meeting
November 3-6, 2010
Chicago, United States

Select Biosciences International Forum on Stem Cells
November 12-13, 2010
Tianjin, China

Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction
January 12-17, 2011
Dillon, United States

Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

Select Biosciences 5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, DC, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


 

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