Volume 11.25 | Jun 30

2020-06-30 | PACN 11.25
Pancreatic Cell News by STEMCELL Technologies
Vol. 11.25 – 30 June, 2020
TOP STORY

Long-Term Culture of Human Pancreatic Slices as a Model to Study Real-Time Islet Regeneration

Using a culture system designed to mimic the physiological oxygenation of the pancreas, researchers demonstrated high viability and preserved endocrine and exocrine function in human pancreatic slices for at least ten days after sectioning.
[Nature Communications]

Full Article

Virtual Conference Exhibition: Organoids
PUBLICATIONSRanked by the impact factor of the journal

Localized Immunosuppression with Tannic Acid Encapsulation Delays Islet Allograft and Autoimmune-Mediated Rejection

Transplantation of poly(N-vinylpyrrolidone)/tannic acid (PVPON/TA)-encapsulated islets was immunomodulatory as gene expression and flow cytometric analysis revealed significantly decreased in immune cell infiltration, synthesis of ROS, inflammatory chemokines, cytokines, CD8 T cell effector responses, and concomitant increases in alternatively-activated M2 macrophage and dendritic cell phenotypes.
[Diabetes]

Abstract

AAV8 Ins1-Cre can Produce Efficient β-Cell Recombination but Requires Consideration of Off-Target Effects

Intraperitoneal AAV8 Ins1-Cre produced efficient β-cell recombination, alongside some hepatic, exocrine pancreas, α-cell, δ-cell, and hypothalamic recombination. Delivery of lower doses via the pancreatic duct retained good rates of β-cell recombination and limited rates of off-target recombination.
[Scientific Reports]

Full Article

Genome-Wide Association Meta-Analysis Identifies GP2 Gene Risk Variants for Pancreatic Cancer

Researchers identified three genome-wide significant loci, of which 16p12.3 have not been reported in the Western population. Functional analyses using cell lines provided supporting evidence of the effect of rs78193826 on KRAS activity.
[Nature Communications]

Full Article

Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors

By manipulating Rb and p53 genes, scientists established a multistep progression model from dysplastic islets to indolent pancreatic neuroendocrine tumors (PanNET) and aggressive metastatic PanNET in mice.
[Cancer Research]

Abstract

CD200 Promotes Immunosuppression in the Pancreatic Tumor Microenvironment

Myeloid-derived suppressor cells isolated from patients with pancreatic ductal adenocarcinoma expressed elevated levels of the CD200 receptor.
[Journal For ImmunoTherapy of Cancer]

Full Article

WD Repeat-Containing Protein 1 Maintains β-Catenin Activity to Promote Pancreatic Cancer Aggressiveness

Scientists identified several previous functional unknown proteins implicated in the progression of pancreatic ductal adenocarcinoma (PDAC), and provided new insight into the oncogenic roles of WD repeat-containing protein 1 in PDAC development.
[British Journal of Cancer]

Abstract

High Expression of AMAP1, An ARF6 Effector, Is Associated with Elevated Levels of PD-L1 and Fibrosis of Pancreatic Cancer

With an aim to understand whether the ARF6-AMAP1 pathway was critically involved in the elevated levels of PD-L1 and fibrosis of pancreatic ductal carcinoma, investigators analyzed the relationship between AMAP1 and these malignant phenotypes.
[Cell Communication and Signaling]

Full Article

Additive Clinical Impact of Epidermal Growth Factor Receptor and Podocalyxin-Like Protein Expression in Pancreatic and Periampullary Adenocarcinomas

The effect of transforming growth factor β-induced expression and siRNA-mediated knockdown of podocalyxin-like protein and epidermal growth factor receptor, were investigated in pancreatic cancer cells in vitro.
[Scientific Reports]

Full Article

Pathogen infection studies lacked an optimal culture system. Then she used organoids.
REVIEWS

Emerging Routes to the Generation of Functional β-Cells for Diabetes Mellitus Cell Therapy

Substantial advances have been made in producing mature β-cells from human pluripotent stem cells that respond appropriately to dynamic changes in glucose concentrations in vitro and rapidly function in vivo following transplantation in mice.
[Nature Reviews Endocrinology]

Abstract

Functional Loss of Pancreatic Islets in Type 2 Diabetes: How Can We Halt It?

The authors provide a view of the experimental and clinical evidence on the ability of available anti-diabetes drugs to exert protective effects on beta-cells, with a specific focus on human pancreatic islets and clinical trials.
[Metabolism-Clinical and Experimental]

Abstract

INDUSTRY AND POLICY NEWS

Corcept Therapeutics Initiates Phase III Trial of Relacorilant Plus Nab-Paclitaxel in Patients with Metastatic Pancreatic Cancer

Corcept Therapeutics Incorporated announced enrollment of the first patient in RELIANT, an open-label, Phase III trial of relacorilant in combination with nab-paclitaxel in patients with metastatic pancreatic cancer.
[Corcept Therapeutics Incorporated]

Press Release

IM Therapeutics Announces First Patient Dosed in Phase I Study of its Lead Drug IMT-002 for Type 1 Diabetes

ImmunoMolecular Therapeutics announced the dosing of the first patient in a Phase I study of IMT-002, an oral small molecule drug designed as a selective HLA-DQ8 blocker for the treatment of type 1 diabetes.
[IM Therapeutics]

Press Release

Mounting Clues Suggest the Coronavirus Might Trigger Diabetes

Evidence from tissue studies and some people with COVID-19 shows that the virus damages insulin-producing cells.
[Nature News]

Editorial

NIH’s New Sexual-Harassment Rules Are Still Too Weak, Say Critics

On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
[Nature News]

Editorial

FEATURED EVENT

Micro-CT: Fancy Gadget or Indispensable Technology towards Accurate Quantification of Lung Disease and Therapy?

July 9
Virtual

> See All Events

JOB OPPORTUNITIES

Postdoctoral Positions – Cancer Genomics/Computational Biology

Stanford Institute for Stem Cell Biology and Regenerative Medicine ( – Stanford, California, United States

Lab Manager – Pancreatic Ductal Adenocarcinoma

Cold Spring Harbor Laboratory – Long Island, New York, United States

Postdoctoral Fellow in Diabetes, Molecular Metabolism and Cardiovascular Research

Cornell University – New York City, New York, United States

Postdoctoral Scholar – Developmental & Stem Cell Biology

University of California – San Francisco, California, United States

Postdoctoral Scientist Position – Drug Vulnerabilities of Pancreatic Cancer

Klinikum rechts der Isar der Technischen Universität München – Munich, Germany

> See All Jobs

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